OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C-difficile Infection

被引：159

作者：

Louie, Thomas J.

Emery, Judy

Krulicki, Walter

Byrne, Brendan

Mah, Manuel

机构：

[1] Univ Calgary, Dept Med, Div Infect Dis, Calgary, AB, Canada

[2] Univ Calgary, Dept Microbiol Infect Dis, Calgary, AB, Canada

[3] Calgary Hlth Reg, Infect Prevent & Control Program, Calgary, AB, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 01期

关键词：

TIACUMICINS; VANCOMYCIN; COMPLEX;

D O I：

10.1128/AAC.01443-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.

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收藏

页码：261 / 263

页数：3

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