A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles

被引：42

作者：

Chen, Wei-Hai ^{[1
,2
]}

Chen, Jing-Xiao ^{[1
,2
]}

Cheng, Han ^{[1
,2
]}

Chen, Chang-Sheng ^{[1
,2
]}

Yang, Juan ^{[1
,2
]}

Xu, Xiao-Ding ^{[1
,2
]}

Wang, Yan ^{[3
]}

Zhuo, Ren-Xi ^{[1
,2
]}

Zhang, Xian-Zheng ^{[1
,2
]}

机构：

[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[3] Chinese Acad Sci, Inst Hydrobiol, Anal & Testing Ctr, Wuhan 430072, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 57期

基金：

中国国家自然科学基金;

关键词：

DRUG-DELIVERY; DESIGN; SIZE; DNA;

D O I：

10.1039/c3cc43283a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Gold nanoparticles functionalized with pro-apoptotic peptide (PAP-AuNPs) were fabricated, which were able to lead to programmed cell-death by damaging mitochondria.

引用

页码：6403 / 6405

页数：3

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