EMT, MET, Plasticity, and Tumor Metastasis

被引：1039

作者：

Bakir, Basil ^{[1
]}

Chiarella, Anna M. ^{[2
]}

Pitarresi, Jason R. ^{[1
]}

Rustgi, Anil K. ^{[2
]}

机构：

[1] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[2] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

TRENDS IN CELL BIOLOGY | 2020年 / 30卷 / 10期

关键词：

E-CADHERIN EXPRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; INFLAMMATORY BREAST-CANCER; ACTIVATOR ZEB1; ALPHA-CATENIN; GAMMA-CATENIN; BETA-CATENIN; OVARIAN; CELLS; DISSEMINATION;

D O I：

10.1016/j.tcb.2020.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cancer cell identity and plasticity are required in transition states, such as epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), in primary tumor initiation, progression, and metastasis. The functional roles of EMT, MET, and the partial state (referred to as pEMT) may vary based on the type of tumor, the state of dissemination, and the degree of metastatic colonization. Herein, we review EMT, MET, pEMT, and plasticity in the context of tumor metastasis.

引用

页码：764 / 776

页数：13

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