A model of focal cancer in rabbit lymph nodes

被引：7

作者：

Jiang, DY ^{[1
]}

Gazelle, GS ^{[1
]}

Wolf, GL ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP, CTR IMAGING & PHARMACEUT RES, BOSTON, MA 02129 USA

来源：

ACADEMIC RADIOLOGY | 1996年 / 3卷 / 02期

关键词：

cancer; lymph node; computed tomography lymphography; popliteal node;

D O I：

10.1016/S1076-6332(05)80386-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Rationale and Objectives. We sought to develop a model of focal cancer in the Methods. Under computed tomography (CT) guidance, 4-5 million VX2 cells were directly injected into the popliteal nodes of 14 anesthetized New Zealand White rabbits. Fifteen to 18 days later, percutaneous lymphography was performed with CT scanning using radiopaque nanoparticulates and massage, Histologic correlation also was obtained. Results. In 12 of the 14 animals, focal lesions were successfully created within (n = 6) and adjacent (n = 6) to the node, and all animals appeared to be healthy when euthanized. Within 15 min after massage, CT lymphography showed homo normal node regions and no enhancement of cancer. There was good agreement between histology and lymphography. Conclusion. This method is suitable as a model to test for diagnostic and therapeutic interventions.

引用

页码：159 / 162

页数：4