Chemical Strategies for Generating Protein Biochips

被引:477
作者
Jonkheijm, Pascal [1 ,2 ]
Weinrich, Dirk [1 ,2 ]
Schroeder, Hendrik [1 ]
Niemeyer, Christof M. [1 ]
Waldmann, Herbert [1 ,2 ]
机构
[1] Tech Univ Dortmund, Fac Chem, D-44227 Dortmund, Germany
[2] Max Planck Inst Mol Physiol, Dept Biol Chem, D-44227 Dortmund, Germany
关键词
chemoselectivity; immobilization; protein biochips; protein patterns; regioselectivity;
D O I
10.1002/anie.200801711
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Protein biochips are at the heart of many medical and bioanalytical applications. Increasing interest has been focused on surface activation and subsequent functionalization strategies for immobilizing these biomolecules. Different approaches using covalent and noncovalent chemistry are reviewed; particular emphasis is placed on the chemical specificity of protein attachment and on retention of protein function. Strategies for creating protein patterns (as opposed to protein arrays) are also outlined. An outlook on promising and challenging future directions for protein biochip research and applications is also offered. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:9618 / 9647
页数:30
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