Study of the chemical composition, antioxidant activity and anti-inflammatory activity of essential oil from Vetiveria zizanioides

被引：70

作者：

Chou, Su-Tze ^{[2
]}

Lai, Chia-Pei ^{[2
]}

Lin, Chih-Chien ^{[1
]}

Shih, Ying ^{[1
]}

机构：

[1] Providence Univ, Dept Cosmet Sci, Taichung 43301, Taiwan

[2] Providence Univ, Dept Food & Nutr, Taichung 43301, Taiwan

来源：

FOOD CHEMISTRY | 2012年 / 134卷 / 01期

关键词：

Antimicrobial; Antioxidant; Anti-inflammatory; Chemical composition; Essential oil; Vetiveria zizanioides; KAPPA-B ACTIVATION; OXIDATIVE STRESS; NITRIC-OXIDE; MEDICINAL-PLANTS; GENE-EXPRESSION; CONSTITUENTS; MACROPHAGES; EXTRACT; CELLS; ASSAY;

D O I：

10.1016/j.foodchem.2012.02.131

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Vetiveria zizanioides (vetiver grass) is well known as an eco-friendly plant that prevents soil erosion and rehabilitates metalliferous polluted land. V. zizanioides is also the major source of vetiver oil for medicine and perfumery. Our study identified 25 compounds in V. zizanioides essential oil (VZ-EO). The major components were cedr-8-en-13-ol (12.4%), alpha-amorphene (7.80%), beta-vatirenene (5.94%) and alpha-gurjunene (5.91%). VZ-EO may suppress the inflammatory responses of LPS-stimulated RAW 264.7 macrophages, including nitric oxide production and cell apoptosis, by regulating the expression of the inflammation-related enzymes heme oxygenase-1, inducible nitric oxide synthase and cyclooxygenase-2 (inducible cyclooxygenase) and the inflammatory cytokines tumour necrosis factor-alpha, interleukin-1 beta and interferon-beta. Additionally, the anti-inflammatory activity of VZ-EO correlated with its antioxidant activity of decreasing LPS-induced superoxide anion production and malondialdehyde levels. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：262 / 268

页数：7

共 31 条

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