Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution

被引：8

作者：

Ahmadi, R. ^{[1
]}

Ranjbarnodeh, E. ^{[2
]}

Gu, N. ^{[3
]}

机构：

[1] Univ Tehran Med Sci, Ctr Mol & Cellular Imaging 1Res, Tehran, Iran

[2] Islamic Azad Univ, E Tehran Branch, Tehran, Iran

[3] Jiangsu Key Lab Biomat & Devices, Nanjing, Jiangsu, Peoples R China

来源：

MATERIALS SCIENCE-POLAND | 2012年 / 30卷 / 04期

关键词：

coprecipitation; nanoparticles; electron microscopy; biocompatibility;

D O I：

10.2478/s13536-012-0048-6

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Cysteine capped magnetite nanoparticles (10 to 20 nm) were synthesized via coprecipitation method under ultrasonic irradiation. The influence of pH value of the solution and cysteine addition on the size distribution and hydrodynamic size of nanoparticles were studied via TEM and PCS methods, respectively. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. Coating density was calculated using TGA and TEM results. Cytotoxicity assessment performed by incubation of L929 cells, confirmed that ferrofluids are biocompatible. MRI studies conducted on rats demonstrated suitability of synthesized nanoparticles as contrast agents, especially for imaging of the lymph nodes.

引用

收藏

页码：382 / 389

页数：8

相关论文

共 21 条

[1]

AVRAMI BEHAVIOR OF MAGNETITE NANOPARTICLES FORMATION IN CO-PRECIPITATION PROCESS [J].

Ahmadi, R. ;

Hosseini, H. R. Madaah ;

Masoudi, A. .

JOURNAL OF MINING AND METALLURGY SECTION B-METALLURGY, 2011, 47 (02) :211-218

[2]

Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy [J].

Ang, K. L. ;

Venkatraman, S. ;

Ramanujan, R. V. .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2007, 27 (03) :347-351

[3]

Iron oxide-enhanced MR lymphography: initial experience [J].

Bellin, MF ;

Beigelman, C ;

Precetti-Morel, S .

EUROPEAN JOURNAL OF RADIOLOGY, 2000, 34 (03) :257-264

[4]

Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells [J].

Bulte, JWM ;

Douglas, T ;

Witwer, B ;

Zhang, SC ;

Strable, E ;

Lewis, BK ;

Zywicke, H ;

Miller, B ;

van Gelderen, P ;

Moskowitz, BM ;

Duncan, ID ;

Frank, JA .

NATURE BIOTECHNOLOGY, 2001, 19 (12) :1141-1147

[5]

A facile biomolecule-assisted approach for fabricating α-Fe2O3 nanowires in solution [J].

Chen, Xiangying ;

Zhang, Zhongjie ;

Qiu, Zhiguo ;

Shi, Chengwu ;

Li, Xueliang .

SOLID STATE COMMUNICATIONS, 2006, 140 (06) :267-269

[6]

Gold-coated iron nanoparticles:: a novel magnetic resonance agent for T1 and T2 weighted imaging [J].

Cho, SJ ;

Jarrett, BR ;

Louie, AY ;

Kauzlarich, SM .

NANOTECHNOLOGY, 2006, 17 (03) :640-644

[7]

Synthesis of monodisperse magnetite nanoparticles via chitosan-poly (acrylic acid) template and their application in MRI [J].

Feng, B. ;

Hong, R. Y. ;

Wu, Y. J. ;

Liu, G. H. ;

Zhong, L. H. ;

Zheng, Y. ;

Ding, J. M. ;

Wei, D. G. .

JOURNAL OF ALLOYS AND COMPOUNDS, 2009, 473 (1-2) :356-362

[8]

Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery [J].

Guo, Shaojun ;

Li, Dan ;

Zhang, Lime ;

Li, Jing ;

Wang, Erkang .

BIOMATERIALS, 2009, 30 (10) :1881-1889

[9]

Facile synthesis of single crystalline α-Fe2O3 ellipsoidal nanoparticles and its catalytic performance for removal of carbon monoxide [J].

Hu, Chaoquan ;

Gao, Zhenghong ;

Yang, Xiaorui .

MATERIALS CHEMISTRY AND PHYSICS, 2007, 104 (2-3) :429-433

[10]

A longitudinal study of R2* and R2 magnetic resonance imaging relaxation rate measurements in murine liver after a single administration of 3 different iron oxide-based contrast agents [J].

Kalber, TL ;

Smith, CJ ;

Howe, FA ;

Griffiths, JR ;

Ryan, AJ ;

Waterton, JC ;

Robinson, SP .

INVESTIGATIVE RADIOLOGY, 2005, 40 (12) :784-791