Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery

被引：368

作者：

Guo, Shaojun ^{[1
,2
]}

Li, Dan ^{[1
]}

Zhang, Lime ^{[1
,2
]}

Li, Jing ^{[1
,2
]}

Wang, Erkang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

BIOMATERIALS | 2009年 / 30卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Mesoporous structure; Magnetic nanoparticle; Biomedicine; Drug delivery; Superparamagnetic; IRON-OXIDE NANOPARTICLES; ONE-POT SYNTHESIS; IN-VIVO; NANOCRYSTALS; THERAPY; NANOSTRUCTURES; PARTICLES; VESICLES; CANCER; PHASE;

D O I：

10.1016/j.biomaterials.2008.12.042

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this contribution, we report a facile, gram-scale, low-cost route to prepare monodisperse superparamagnetic single-crystal magnetite NPs with mesoporous structure (MSSMN) via a very simple solvothermal method. The formation mechanism of MSSMN is also discussed and we think that Ostwald ripening probably plays an important role in this synthesis process. It is also interestingly found that the size and morphology of mesoporous Fe3O4 NPs can be easily controlled by changing the amount of NaOH and 1,2-ethylenediamine (ETH). Most importantly, the MSSMN can be used as an effective drug delivery carrier. A typical anticancer drug, doxorubicin (Dox), is used for drug loading, and the release behaviors of Dox in two different pH solutions are studied. The results indicate that the MSSMN has a high drug loading capacity and favorable release property for Dox; thus, it is very promising for the application in drug delivery. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1881 / 1889

页数：9

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