Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer

被引：624

作者：

Cheng, Yu ^{[2
]}

Samia, Anna C. ^{[2
]}

Meyers, Joseph D. ^{[1
]}

Panagopoulos, Irene ^{[3
]}

Fei, Baowei ^{[1
,3
]}

Burda, Clemens ^{[2
]}

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Ctr Chem Dynam & Nanomat Res, Dept Chem, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 32期

关键词：

D O I：

10.1021/ja801631c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.

引用

页码：10643 / 10647

页数：5

共 39 条

[1] Current status of phthalocyanines in the photodynamic therapy of cancer [J].

Allen, CM ;

Sharman, WM ;

Van Lier, JE .

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2001, 5 (02) :161-169

[2] Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions [J].

Bearinger, JP ;

Terrettaz, S ;

Michel, R ;

Tirelli, N ;

Vogel, H ;

Textor, M ;

Hubbell, JA .

NATURE MATERIALS, 2003, 2 (04) :259-264

[3] High salt stability and protein resistance of poly(L-lysine)-g-poly(ethylene glycol) copolymers covalently immobilized via aldehyde plasma polymer interlayers on inorganic and polymeric substrates [J].

Blaettler, Thomas M. ;

Pasche, Stephanie ;

Textor, Marcus ;

Griesser, Hans J. .

LANGMUIR, 2006, 22 (13) :5760-5769

[4] SYNTHESIS OF THIOL-DERIVATIZED GOLD NANOPARTICLES IN A 2-PHASE LIQUID-LIQUID SYSTEM [J].

BRUST, M ;

WALKER, M ;

BETHELL, D ;

SCHIFFRIN, DJ ;

WHYMAN, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (07) :801-802

[5] Photodynamic therapy and anti-tumour immunity [J].

Castano, Ana P. ;

Mroz, Pawel ;

Hamblin, Michael R. .

NATURE REVIEWS CANCER, 2006, 6 (07) :535-545

[6] Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells [J].

Chithrani, BD ;

Ghazani, AA ;

Chan, WCW .

NANO LETTERS, 2006, 6 (04) :662-668

[7] Renal clearance of quantum dots [J].

Choi, Hak Soo ;

Liu, Wenhao ;

Misra, Preeti ;

Tanaka, Eiichi ;

Zimmer, John P. ;

Ipe, Binil Itty ;

Bawendi, Moungi G. ;

Frangioni, John V. .

NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170

[8] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].

Connor, EE ;

Mwamuka, J ;

Gole, A ;

Murphy, CJ ;

Wyatt, MD .

SMALL, 2005, 1 (03) :325-327

[9] Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].

Daniel, MC ;

Astruc, D .

CHEMICAL REVIEWS, 2004, 104 (01) :293-346

[10] Liposomes for photodynamic therapy [J].

Derycke, ASL ;

de Witte, PAM .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (01) :17-30

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