Mechanisms of retroviral mutation

被引：114

作者：

Preston, BD

Dougherty, JP

机构：

[1] UNIV UTAH, DEPT BIOCHEM, SALT LAKE CITY, UT USA

[2] UNIV UTAH, DEPT RADIAT ONCOL, SALT LAKE CITY, UT USA

[3] UNIV UTAH, ECCLES INST HUMAN GENET, SALT LAKE CITY, UT USA

[4] UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, DEPT MOLEC GENET & MICROBIOL, PISCATAWAY, NJ 08854 USA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 01期

关键词：

D O I：

10.1016/0966-842X(96)81500-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.

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页码：16 / 21

页数：6

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