Asymmetric Palladium-Catalyzed Intramolecular α-Arylation of Aldehydes

被引：89

作者：

Garcia-Fortanet, Jorge ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 42期

基金：

美国国家卫生研究院;

关键词：

alpha-arylation; aldehydes; asymmetric catalysis; P ligands; palladium;

D O I：

10.1002/anie.200803809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Phoxy ligand: The first catalytic method for the asymmetric palladium-catalyzed intramolecular α-arylation of α-branched aldehydes was developed (see scheme). This process is distinguished by the high yields and enantioselectivities that can be obtained, making this protocol a useful synthetic tool for further applications. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8108 / 8111

页数：4

共 44 条

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