Radical trifluoromethylation of ketone Li enolates

被引：65

作者：

Itoh, Yoshimitsu ^{[1
]}

Mikami, Koichi ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Sci & Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

来源：

TETRAHEDRON | 2006年 / 62卷 / 30期

关键词：

trifluoromethylation; Li enolate; radical addition;

D O I：

10.1016/j.tet.2006.03.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It has generally been believed that highly basic Li enolates cannot be applied as substrates for radical trifluoromethylation due to defluorination of the alpha-CF3 product. However, Li enolates can be in fact employed for radical trifluoromethylation. Moreover, the reaction is extremely fast and the minimum reaction time is only similar to 1 s. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7199 / 7203

页数：5

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