Sin3: Insight into its transcription regulatory functions

被引：117

作者：

Kadamb, Rama ^{[1
]}

Mittal, Shilpi ^{[1
]}

Bansal, Nidhi ^{[1
]}

Batra, Harish ^{[1
]}

Saluja, Daman ^{[1
]}

机构：

[1] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2013年 / 92卷 / 8-9期

关键词：

Sin3A; Sin3B; Histone deacetylase; Co-repressor complex; Transcriptional regulation; Protein stability; HISTONE DEACETYLASE COMPLEX; ESTROGEN-RECEPTOR-ALPHA; RNA-POLYMERASE-II; CELL-CYCLE; DROSOPHILA SIN3; PAH2; DOMAIN; WILD-TYPE; HETEROCHROMATIN FORMATION; COREPRESSOR MSIN3A; REPRESSOR COMPLEX;

D O I：

10.1016/j.ejcb.2013.09.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor complex functions in transcriptional regulation of several genes and is therefore implicated in the regulation of key biological processes. Knockdown studies have confirmed the role of Sin3 in cellular proliferation, differentiation, apoptosis and cell cycle regulation, emphasizing Sin3 as an essential regulator of critical cellular events in normal and pathological processes. The present review covers the diverse functions of this master transcriptional regulator as well as illustrates the redundant and distinct functions of its two mammalian isoforms. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：237 / 246

页数：10

共 115 条

[1] Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
Alland, L
Muhle, R
Hou, H
Potes, J
Chin, L
SchreiberAgus, N
DePinho, RA
[J]. NATURE, 1997, 387 (6628) : 49 - 55
[2] MAD-MAX TRANSCRIPTIONAL REPRESSION IS MEDIATED BY TERNARY COMPLEX-FORMATION WITH MAMMALIAN HOMOLOGS OF YEAST REPRESSOR SIN3
AYER, DE
LAWRENCE, QA
EISENMAN, RN
[J]. CELL, 1995, 80 (05) : 767 - 776
[3] Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells
Balciunaite, E
Spektor, A
Lents, NH
Cam, H
Riele, HT
Scime, A
Rudnicki, MA
Young, R
Dynlacht, BD
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (18) : 8166 - 8178
[4] A Positive Regulatory Role for the mSin3A-HDAC Complex in Pluripotency through Nanog and Sox2
Baltus, Gretchen A.
Kowalski, Michael P.
Tutter, Antonin V.
Kadam, Shilpa
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (11) : 6998 - 7006
[5] Tumor Suppressor Protein p53 Recruits Human Sin3B/HDAC1 Complex for Down-Regulation of Its Target Promoters in Response to Genotoxic Stress
Bansal, Nidhi
Kadamb, Rama
Mittal, Shilpi
Vig, Leena
Sharma, Raisha
Dwarakanath, Bilikere S.
Saluja, Daman
[J]. PLOS ONE, 2011, 6 (10):
[6] Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function
Barnes, Valerie L.
Strunk, Bethany S.
Lee, Icksoo
Huettemann, Maik
Pile, Lori A.
[J]. BMC BIOCHEMISTRY, 2010, 11
[7] Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A
Miska, EA
McCance, DJ
Reid, JL
Bannister, AJ
Kouzarides, T
[J]. NATURE, 1998, 391 (6667) : 597 - 601
[8] Solution structure of the interacting domains of the Mad-Sin3 complex: Implications for recruitment of a chromatin-modifying complex
Brubaker, K
Cowley, SM
Huang, K
Loo, L
Yochum, GS
Ayer, DE
Eisenman, RN
Radhakrishnan, I
[J]. CELL, 2000, 103 (04) : 655 - 665
[9] Co-repressors 2000
Burke, LJ
Baniahmad, A
[J]. FASEB JOURNAL, 2000, 14 (13) : 1876 - 1888
[10] Distinct Role of Kruppel-like Factor 11 in the Regulation of Prostaglandin E2 Biosynthesis
Buttar, Navtej S.
DeMars, Cathrine J.
Lomberk, Gwen
Ilyas, Sumera I.
Bonilla-Velez, Juliana
Achra, Shalini
Rashtak, Shahrooz
Wang, Kenneth K.
Fernandez-Zapico, Martin E.
Urrutia, Raul
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (15) : 11433 - 11444

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