Potential Value and Limitation of Dual Inhibitors of PI3K and mTOR in the Treatment of Cancer

被引：15

作者：

Chen, Jiezhong ^{[1
]}

机构：

[1] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia

来源：

CURRENT CANCER DRUG TARGETS | 2013年 / 13卷 / 02期

关键词：

PHOSPHOINOSITIDE 3-KINASE PATHWAY; MULTIPLE SIGNAL PATHWAYS; THERAPEUTIC IMPLICATIONS; COLON-CANCER; OBESITY; KINASE; TARGET; RAC; METAANALYSIS; LEUKEMIA;

D O I：

10.2174/1568009611313020001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

引用

页码：117 / 120

页数：4

共 49 条

[1]

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase [J].

Algire, Carolyn ;

Amrein, Lilian ;

Zakikhani, Mahvash ;

Panasci, Lawrence ;

Pollak, Michael .

[2]

Role of the p70S6K pathway in regulating the actin cytoskeleton and cell migration [J].

Berven, LA ;

Willard, FS ;

Crouch, MF .

EXPERIMENTAL CELL RESEARCH, 2004, 296 (02) :183-195

[3]

Rac1 GTPase: A "Rac" of All Trades [J].

Bosco, E. E. ;

Mulloy, J. C. ;

Zheng, Y. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (03) :370-374

[4]

Rho and Rac take center stage [J].

Burridge, K ;

Wennerberg, K .

CELL, 2004, 116 (02) :167-179

[5]

The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

[6]

Lewis C. Cantley [J].

Cantley, Lewis C. .

CURRENT BIOLOGY, 2009, 19 (14) :R540-R541

[7]

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications [J].

Carnero, Amancio ;

Blanco-Aparicio, Carmen ;

Renner, Oliver ;

Link, Wolfgang ;

Leal, Juan F. M. .

CURRENT CANCER DRUG TARGETS, 2008, 8 (03) :187-198

[8]

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [J].

Carpten, John D. ;

Faber, Andrew L. ;

Horn, Candice ;

Donoho, Gregory P. ;

Briggs, Stephen L. ;

Robbins, Christiane M. ;

Hostetter, Galen ;

Boguslawski, Sophie ;

Moses, Tracy Y. ;

Savage, Stephanie ;

Uhlik, Mark ;

Lin, Aimin ;

Du, Jian ;

Qian, Yue-Wei ;

Zeckner, Douglas J. ;

Tucker-Kellogg, Greg ;

Touchman, Jeffrey ;

Patel, Ketan ;

Mousses, Spyro ;

Bittner, Michael ;

Schevitz, Richard ;

Lai, Mei-Huei T. ;

Blanchard, Kerry L. ;

Thomas, James E. .

NATURE, 2007, 448 (7152) :439-U1

[9]

Multiple signal pathways in obesity-associated cancer [J].

Chen, J. .

OBESITY REVIEWS, 2011, 12 (12) :1063-1070

[10]

Chen J., 2012, TRANSL GASTROINTEST, V1, P44, DOI DOI 10.3978/j.issn.2224-4778.2011.11.01

← 1 2 3 4 5 →