Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France

被引:104
作者
Cattoir, Vincent [1 ,2 ]
Poirel, Laurent [1 ]
Nordmann, Patrice [1 ]
机构
[1] Univ Paris Sud, Hop Bicetre, AP HP,INSERM,Serv Bacteriol Virol, Fac Med,Emerging Resistance Antibiot U914, F-94275 Le Kremlin Bicetre, France
[2] Univ Paris 12, Hop Henri Mondor, AP HP, Fac Med,Serv Bacteriol Virol Hyg, F-94010 Creteil, France
关键词
D O I
10.1128/AAC.00638-08
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
One hundred twenty-one extended-spectrum beta-lactamse-producing enterobacterial clinical isolates were screened for the qepA gene. A single CTX-M-15-positive Escherichia coli isolate (0.8%) that produced the putative pump QepA2 was identified. This qepA2 gene was located onto a 90-kb mobilizable plasmid that conferred reduced susceptibility to hydrophilic fluoroquinolones.
引用
收藏
页码:3801 / 3804
页数:4
相关论文
共 19 条
[1]   Identification of plasmids by PCR-based replicon typing [J].
Carattoli, A ;
Bertini, A ;
Villa, L ;
Falbo, V ;
Hopkins, KL ;
Threlfall, EJ .
JOURNAL OF MICROBIOLOGICAL METHODS, 2005, 63 (03) :219-228
[2]   Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp. [J].
Cattoir, Vincent ;
Poirel, Laurent ;
Aubert, Camille ;
Soussy, Claude-James ;
Nordmann, Patrice .
EMERGING INFECTIOUS DISEASES, 2008, 14 (02) :231-237
[3]   Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates [J].
Cattoir, Vincent ;
Poirel, Laurent ;
Rotimi, Vincent ;
Soussy, Claude-James ;
Nordmann, Patrice .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (02) :394-397
[4]   In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid [J].
Cattoir, Vincent ;
Lesprit, Philippe ;
Lascols, Christine ;
Denamur, Erik ;
Legrand, Patrick ;
Soussy, Claude-James ;
Cambau, Emmanuelle .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (05) :1054-1057
[5]  
*CLIN LAB STAND I, 2008, PERF STAND ANT SUS S
[6]   Molecular epidemiology of the integron-located VEB-1 extended-spectrum β-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand [J].
Girlich, D ;
Poirel, L ;
Leelaporn, A ;
Karim, A ;
Tribuddharat, C ;
Fennewald, M ;
Nordmann, P .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (01) :175-182
[7]   Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneti 2b [J].
Hata, M ;
Suzuki, M ;
Matsumoto, M ;
Takahashi, M ;
Sato, K ;
Ibe, S ;
Sakae, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :801-803
[8]   qnrB, another plasmid-mediated gene for quinolone resistance [J].
Jacoby, GA ;
Walsh, KE ;
Mills, DM ;
Walker, VJ ;
Oh, H ;
Robicsek, A ;
Hooper, DC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1178-1182
[9]   FACTORS AFFECTING THE ISOLATION OF CCC DNA FROM STREPTOMYCES-LIVIDANS AND ESCHERICHIA-COLI [J].
KIESER, T .
PLASMID, 1984, 12 (01) :19-36
[10]   Quinolone resistance from a transferable plasmid [J].
Martínez-Martínez, L ;
Pascual, A ;
Jacoby, GA .
LANCET, 1998, 351 (9105) :797-799