Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression

被引：45

作者：

Abrams, Scott I. ^{[1
]}

Waight, Jeremy D. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期

关键词：

myeloid-derived suppressor cells; immunosuppression; tumor progression; immunosurveillance; inflammation and cancer; COLONY-STIMULATING FACTOR; SUPPRESSOR-CELLS;

D O I：

10.4161/onci.19334

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumorderived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrated that tumor-derived G-CSF drives granulocytic MDSC formation, thus providing new insights into myeloid-tumor biology.

引用

页数：2

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