AMPK, insulin resistance, and the metabolic syndrome

被引：684

作者：

Ruderman, Neil B. ^{[1
,2
,3
]}

Carling, David ^{[4
]}

Prentki, Marc ^{[5
,6
,7
,8
]}

Cacicedo, Jose M. ^{[1
,2
,3
]}

机构：

[1] Boston Univ, Diabet & Metab Res Unit, Sch Med, Boston, MA 02118 USA

[2] Boston Univ, Dept Med, Sch Med, Boston, MA 02118 USA

[3] Boston Univ, Endocrinol Sect, Sch Med, Boston, MA 02118 USA

[4] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Hammersmith Hosp, Cellular Stress Grp, London, England

[5] Univ Montreal, Montreal Diabet Res Ctr, Montreal, PQ, Canada

[6] Univ Montreal, CRCHUM, Montreal, PQ, Canada

[7] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada

[8] Univ Montreal, Dept Biochem, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 07期

基金：

英国医学研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; MUSCLE GLUCOSE-METABOLISM; NITRIC-OXIDE SYNTHASE; FATTY-ACID OXIDATION; ADIPOSE-TISSUE; MALONYL-COA; SKELETAL-MUSCLE; ENDOTHELIAL-CELLS; BARIATRIC SURGERY;

D O I：

10.1172/JCI67227

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Insulin resistance (IR) and hyperinsulinemia are hallmarks of the metabolic syndrome, as are central adiposity, d.yslipidemia, and a predisposition to type 2 diabetes, atherosclerotic cardiovascular disease, hypertension, and certain cancers. Regular exercise and calorie restriction have long been known to increase insulin sensitivity and decrease the prevalence of these disorders. The subsequent identification of AMP-activated protein kinase (AMPK) and its activation by exercise and fuel deprivation have led to studies of the effects of AMPK on both IR and metabolic syndrome-related diseases. In this review, we evaluate this body of literature, with special emphasis on the hypothesis that dysregulation of AMPK is both a pathogenic factor for these disorders in humans and a target for their prevention and therapy.

引用

页码：2764 / 2772

页数：9

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