Aryl ferrophites - A new class of ligands for asymmetric catalysis

被引:31
作者
Albrow, Victoria E. [1 ]
Blake, Alexander J. [1 ]
Fryatt, Ross [1 ]
Wilson, Claire [1 ]
Woodward, Simon [1 ]
机构
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
关键词
ferrocenyl ligands; P ligands; phosphites; asymmetric catalysis;
D O I
10.1002/ejoc.200600071
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantiopure lithiated 1,2-ferrocenes, [CpFe{1,2-eta(5)-C5H3(Ar)-(Li)}] (Ar = Ph, 4-CF3C6H4, 1-C10H7) react readily with PhOP(OR)(2) to yield [CpFe{1,2-eta(5)-C5H3(Ar)P(OR)(2)}] (R = Ph, 1, 1'-biphenyl-based, 1, 1'-binaphthyl-based) efficiently. Traditional routes to these species, involving the use of chlorophosphites CIP(OR)(2) were found to be ineffective. These "ferrophite" ligands have been characterised by X-ray crystallography (4 examples) and shown to be effective in both nickel-catalysed addition of AlMe3 to PhCHO (up to 77% ee) and copper(I)-catalysed additions of organoaluminium reagents to enones (up to 92% ee).
引用
收藏
页码:2549 / 2557
页数:9
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