Aryl ferrophites - A new class of ligands for asymmetric catalysis

被引：31

作者：

Albrow, Victoria E. ^{[1
]}

Blake, Alexander J. ^{[1
]}

Fryatt, Ross ^{[1
]}

Wilson, Claire ^{[1
]}

Woodward, Simon ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 11期

关键词：

ferrocenyl ligands; P ligands; phosphites; asymmetric catalysis;

D O I：

10.1002/ejoc.200600071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiopure lithiated 1,2-ferrocenes, [CpFe{1,2-eta(5)-C5H3(Ar)-(Li)}] (Ar = Ph, 4-CF3C6H4, 1-C10H7) react readily with PhOP(OR)(2) to yield [CpFe{1,2-eta(5)-C5H3(Ar)P(OR)(2)}] (R = Ph, 1, 1'-biphenyl-based, 1, 1'-binaphthyl-based) efficiently. Traditional routes to these species, involving the use of chlorophosphites CIP(OR)(2) were found to be ineffective. These "ferrophite" ligands have been characterised by X-ray crystallography (4 examples) and shown to be effective in both nickel-catalysed addition of AlMe3 to PhCHO (up to 77% ee) and copper(I)-catalysed additions of organoaluminium reagents to enones (up to 92% ee).

引用

页码：2549 / 2557

页数：9

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