Copper-catalyzed enantioselective conjugate addition of diethylzinc to α,β-unsaturated carbonyl compounds using diphosphonites as chiral ligands

被引：54

作者：

Reetz, MT ^{[1
]}

Gosberg, A ^{[1
]}

Moulin, D ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 07期

关键词：

enones; zinc and compound; addition reactions; asymmetric synthesis;

D O I：

10.1016/S0040-4039(01)02355-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

BINOL-based diphosphonites in which ferrocene functions as the achiral backbone are excellent chiral ligands in the Cu(OTf)(2)-catalyzed conjugate addition of Et2Zn to enones, enantioselectivities of up to 99% being observed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1189 / 1191

页数：3

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