New chiral oxazoline-phosphite ligands for the enantioselective copper-catalyzed 1,4-addition of organozinc reagents to enones

被引：161

作者：

Escher, IH ^{[1
]}

Pfaltz, A ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

TETRAHEDRON | 2000年 / 56卷 / 18期

关键词：

asymmetric induction; addition reactions; oxazolines; copper and compounds;

D O I：

10.1016/S0040-4020(00)00143-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new P,N-ligands with a binaphthyl and an oxazoline moiety were prepared, which are efficient ligands for the enantioselective copper-catalyzed 1,4-addition of organozinc reagents to enones. Increasing the steric bulk in the 3,3'-position of binaphthyl from an H to a biphenylyl moiety improved the ee from 65 to 94% in the reaction of diethylzinc with cyclopentenone. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2879 / 2888

页数：10

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