A highly enantioselective synthesis of cyclic α-amino acids involving a one-pot, single catalyst, tandem hydrogenation-hydroformylation sequence

被引：40

作者：

Teoh, E

Campi, EM

Jackson, WR

Robinson, AJ

机构：

[1] Monash Univ, Ctr Green Chem, Clayton, Vic 3800, Australia

[2] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 09期

关键词：

D O I：

10.1039/b200374k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tandem enantioselective hydrogenation followed by a hydroformylation-cyclisation sequence leading to cyclic alpha amino acids with ee's > 95% can be achieved in a single pot, one catalyst system by successive reactions of prochiral dienamide esters with H-2 followed by H-2/CO using Rh(I)-DuPHOS.

引用

收藏

页码：978 / 979

页数：2

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