InBr3-catalyzed intramolecular cyclization of 2-alkynylanilines leading to polysubstituted indole and its application to one-pot synthesis of an amino acid precursor

被引：73

作者：

Sakai, N ^{[1
]}

Annaka, K ^{[1
]}

Konakahara, T ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Sci & Technol, Dept Pure & Appl Chem, RIKADAI, Noda, Chiba 2788510, Japan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 05期

关键词：

indium bromide; indole; intramolecular cyclization; 2-ethynylaniline;

D O I：

10.1016/j.tetlet.2005.11.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe InBr3-catalyzed cyclization of 2-alkynylanifine derivatives having a variety of functional groups producing polysubstituted indoles. This methodology could be applied to the one-pot synthesis of an amino acid precursor by the addition of a catalytic amount of the indium salt, an imine, and TMSCI. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：631 / 634

页数：4

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