Prostate cancer genomics: towards a new understanding

被引：95

作者：

Witte, John S. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Inst Human Genet, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

WIDE ASSOCIATION; SEQUENCE VARIANTS; CHROMOSOME; 8Q24; MULTIPLE LOCI; GENE FUSIONS; RISK; SUSCEPTIBILITY; DEATH;

D O I：

10.1038/nrg2507

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent genetics and genomics studies of prostate cancer have helped to clarify the genetic basis of this common but complex disease. Genome-wide studies have detected numerous variants associated with disease as well as common gene fusions and expression 'signatures' in prostate tumours. On the basis of these results, some advocate gene-based individualized screening for prostate cancer, although such testing might only be worthwhile to distinguish disease aggressiveness. Lessons learned from these studies provide strategies for further deciphering the genetic causes of prostate cancer and other diseases.

引用

页码：77 / 82

页数：6

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