Synthesis and properties of (6,7-dimethoxy-4-coumaryl)alanine: A fluorescent peptide label

被引：16

作者：

Bennett, FA ^{[1
]}

Barlow, DJ ^{[1
]}

Dodoo, ANO ^{[1
]}

Hider, RC ^{[1
]}

Lansley, AB ^{[1
]}

Lawrence, MJ ^{[1
]}

Marriott, C ^{[1
]}

Bansal, SS ^{[1
]}

机构：

[1] Kings Coll London, Dept Pharm, London SW3 6LX, England

来源：

ANALYTICAL BIOCHEMISTRY | 1999年 / 270卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/abio.1999.4081

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of racemic and L-(6,7-dimethoxy-4-coumaryl)alanine (Dmca) is described and some spectral and physicochemical properties are reported. The utility of Dmca as a highly sensitive and specific label for the quantitative detection of synthetic peptides in HPLC and in minimal essential media (MEM) is also described. (C) 1999 Academic Press.

引用

页码：15 / 23

页数：9

共 31 条

[21] TRIALKYLSILANES AS SCAVENGERS FOR THE TRIFLUOROACETIC-ACID DEBLOCKING OF PROTECTING GROUPS IN PEPTIDE-SYNTHESIS [J].

PEARSON, DA ;

BLANCHETTE, M ;

BAKER, ML ;

GUINDON, CA .

TETRAHEDRON LETTERS, 1989, 30 (21) :2739-2742

[22] APPLICATIONS OF CAPILLARY ELECTROPHORESIS IN PHARMACEUTICAL ANALYSIS [J].

RABEL, SR ;

STOBAUGH, JF .

PHARMACEUTICAL RESEARCH, 1993, 10 (02) :171-186

[23]

RANDALL CS, 1991, PEPTIDE PROTEIN DRUG, P203

[24]

RILEY CM, 1994, PHARM BIOMEDICAL APP, P41

[25] A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity [J].

Soleilhac, JM ;

Cornille, F ;

Martin, L ;

Lenoir, C ;

FournieZaluski, MC ;

Roques, BP .

ANALYTICAL BIOCHEMISTRY, 1996, 241 (01) :120-127

[26] FLUORESCENCE CHARACTERISTICS OF METHOXYCOUMARINS AS NOVEL FLUOROPHORES [J].

TAKADATE, A ;

MASUDA, T ;

MURATA, C ;

TANAKA, T ;

IRIKURA, M ;

GOYA, S .

ANALYTICAL SCIENCES, 1995, 11 (01) :97-101

[27] DANSYLATION OF AMINO-ACIDS FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ANALYSIS [J].

TAPUHI, Y ;

SCHMIDT, DE ;

LINDNER, W ;

KARGER, BL .

ANALYTICAL BIOCHEMISTRY, 1981, 115 (01) :123-129

[28] New peptide and protein drugs [J].

Vermeij, P ;

Blok, D .

PHARMACY WORLD & SCIENCE, 1996, 18 (03) :87-93

[29] KINETICS OF FOLDING OF LEUCINE-ZIPPER DOMAINS [J].

WENDT, H ;

BERGER, C ;

BAICI, A ;

THOMAS, RM ;

BOSSHARD, HR .

BIOCHEMISTRY, 1995, 34 (12) :4097-4107

[30] ASYMMETRIC-SYNTHESIS OF MONOSUBSTITUTED AND ALPHA,ALPHA-DISUBSTITUTED ALPHA-AMINO-ACIDS VIA DIASTEREOSELECTIVE GLYCINE ENOLATE ALKYLATIONS [J].

WILLIAMS, RM ;

IM, MN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (24) :9276-9286

← 1 2 3 4 →