General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

被引：97

作者：

Li, Feng ^{[1
]}

Xie, Jianjiang ^{[1
]}

Shan, Haixia ^{[1
]}

Sun, Chunlou ^{[1
]}

Chen, Lin ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

RSC ADVANCES | 2012年 / 2卷 / 23期

基金：

中国国家自然科学基金;

关键词：

RUTHENIUM-CATALYZED AMINATION; ASTERISK-IR COMPLEX; OXIDATIVE CYCLIZATION; SELECTIVE SYNTHESIS; BORROWING HYDROGEN; HIGHLY EFFICIENT; TERTIARY-AMINES; ALCOHOLS; ALKYLATION; SULFONAMIDES;

D O I：

10.1039/c2ra21487c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct N-monomethylation of aromatic primary amines, including arylamines, arylsulfonamides and amino-azoles, using methanol as a methylating agent has been accomplished in the presence of a [Cp*IrCl2](2)/NaOH system. From both synthetic and environmental points of view, the reaction is highly attractive because of low catalyst loading, broad substrate scope and excellent selectivities.

引用

页码：8645 / 8652

页数：8

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