A simple method for the quantitative analysis of resin bound thiol groups

被引：55

作者：

Badyal, JP

Cameron, AM

Cameron, NR

Coe, DM

Cox, R

Davis, BG

Oates, LJ

Oye, G

Steel, PG

机构：

[1] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 48期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)01820-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Non-aqueous solutions of Ellman's reagent [5,5'-dithio(2-nitrobenzoic acid), DTNB] can be used to quantify thiols supported on macroporous polystyrene and TentaGel resins. Organic solutions of Ellman's reagent may also be used as a qualitative tests for thiols on a wider range of solid supports. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8531 / 8533

页数：3

共 31 条

[11]

2-A

[12] Analysis of single polymer beads for solid phase combinatorial synthesis: the determination of reactive thiol and within batch polydispersity of bead loadings [J].