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Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

被引：68
作者：
Almeida, Valeria [1 ,2 ]
Levin, Raquel [1 ,2 ]
Peres, Fernanda Fiel [1 ,2 ]
Niigaki, Suzy T. [1 ,2 ]
Calzavara, Mariana B. [2 ]
Zuardi, Antonio W. [3 ,4 ]
Hallak, Jaime E. [3 ,4 ]
Crippa, Jose A. [3 ,4 ]
Abilio, Vanessa C. [1 ,2 ]
机构：
[1] Univ Fed Sao Paulo, Dept Farmacol, UNIFESP, Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Lab Interdisciplinar Neurociencias Clin, Sao Paulo, Brazil
[3] Univ Sao Paulo, Dept Neurociencias & Ciencias Comportamento, BR-14049 Ribeirao Preto, Brazil
[4] Inst Nacl Ciencia & Tecnol Translac Med, INCT TM, CNPq, Ribeirao Preto, Brazil
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2013年 / 41卷
基金：
巴西圣保罗研究基金会;
关键词：
Anxiety; Cannabidiol; Schizophrenia; SHR; Social interaction test; SPONTANEOUSLY HYPERTENSIVE-RATS; ELEVATED PLUS-MAZE; WISTAR-KYOTO WKY; OPEN-FIELD; ANIMAL-MODELS; ENDOCANNABINOID SYSTEM; STEREOTYPED BEHAVIOR; D-AMPHETAMINE; SCHIZOPHRENIA; ANXIETY;
D O I：
10.1016/j.pnpbp.2012.10.024
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. In addition, SHRs present a hyperlocomotion that is reverted by typical and atypical antipsychotics, suggesting that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia as well as the effects of potential antipsychotics drugs. At the same time, an increase in social interaction in control animals similar to that induced by benzodiazepines is used to screen potential anxiolytic drugs. The aim of this study was to investigate the effects of CBD on social interaction presented by control animals (Wistar) and SHRs. The lowest dose of CBD (1 mg/kg) increased passive and total social interaction of Wistar rats. However, the hyperlocomotion and the deficit in social interaction displayed by SHRs were not altered by any dose of CBD. Our results do not support an antipsychotic property of cannabidiol on symptoms-like behaviors in SHRs but reinforce the anxiolytic profile of this compound in control rats. (C) 2012 Elsevier Inc. All rights reserved.
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页码：30 / 35
页数：6
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