Liquid-phase microextraction combined with hollow fiber as a sample preparation technique prior to gas chromatography/mass spectrometry

被引:240
作者
Zhao, LM [1 ]
Lee, HK [1 ]
机构
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
关键词
D O I
10.1021/ac011124c
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Two modes of liquid-phase microextraction (LPME) combined with hollow fiber (HF) were developed for gas chromatography/mass spectrometry (GC/MS). Both methodologies, that is, static LPME with HF and dynamic LPME with HF, involved the use of a small volume of organic solvent impregnated in the hollow fiber, which was held by the needle of a conventional GC syringe. In static LPME/HF, the hollow fiber impregnated with solvent was immersed in the aqueous sample, and the extraction processed under stirring; in dynamic LPME/HF, the solvent was repeatedly withdrawn into and discharged from the hollow fiber by a syringe pump. This is believed to be the first reported instance of a semiautomated liquid microextraction procedure. The performance of the two techniques was demonstrated in the analysis of two PAH compounds in an aqueous sample. Static LPME/HF provided similar to35-fold enrichment in 10 min and good reproducibility (similar to4%). Dynamic LPME/HF could provide higher enrichment (similar to75-fold) in 10 min and even better reproducibility (similar to3%). Both methods allow the direct transfer of extracted analytes to a GC/MS system for analysis.
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收藏
页码:2486 / 2492
页数:7
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