Flow injection chemiluminescence determination of ethamsylate based on permanganate oxidation

被引：27

作者：

Du, JX ^{[1
]}

Li, YH ^{[1
]}

Tang, Y ^{[1
]}

Lu, JR ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Dept Chem, Sch Chem & Mat Sci, Xian 710062, Peoples R China

来源：

ANALYTICAL LETTERS | 2002年 / 35卷 / 03期

关键词：

flow injection; chemiluminescence; ethamsylate; potassium permanganate;

D O I：

10.1081/AL-120002680

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new flow injection chemiluminescence method is described for the determination of ethamsylate. The method is based on the measurement of the chemiluminescence signal produced from oxidation of ethamsylate by potassium permanganate in acidic solution, enhanced by formic acid. The method allows the determination of ethamsylate over the range 1.0 x 10(-8)-2.0 x 10(-6) g ml(-1) with a sample measurement frequency of 180 samples h(-1). The detection limit for ethamsylate is 5 x 10(-9) g ml(-l) and the relative standard deviation is 1.4% for 5.0 x 10(-7) g ml(-1) ethamsylate solution in eleven replicate measurements. The method was successfully applied to the determination of ethamsylate in pharmaceutical preparations. A brief discussion on the chemiluminescence reaction mechanism has also given.

引用

页码：463 / 472

页数：10

共 21 条

[1] DETERMINATION OF MORPHINE BY FLOW-INJECTION ANALYSIS WITH CHEMILUMINESCENCE DETECTION [J].

ABBOTT, RW ;

TOWNSHEND, A ;

GILL, R .

ANALYST, 1986, 111 (06) :635-640

[2] Direct chemiluminescence determination of ascorbic acid using flow injection analysis [J].

Agater, IB ;

Jewsbury, RA .

ANALYTICA CHIMICA ACTA, 1997, 356 (2-3) :289-294

[3] CHEMI-LUMINESCENCE DETECTION OF THE BENZODIAZEPINE LOPRAZOLAM [J].

ANDREWS, ARJ ;

TOWNSHEND, A .

ANALYTICA CHIMICA ACTA, 1989, 227 (01) :65-71

[4] Chemiluminescence determination of naltrexone based on potassium permanganate oxidation [J].

Campiglio, A .

ANALYST, 1998, 123 (05) :1053-1056

[5] FLOW-INJECTION CHEMILUMINOMETRIC DETERMINATION OF EPINEPHRINE, NOREPINEPHRINE, DOPAMINE AND L-DOPA [J].

DEFTEREOS, NT ;

CALOKERINOS, AC ;

EFSTATHIOU, CE .

ANALYST, 1993, 118 (06) :627-632

[6]

*ED COMM PHARM PEO, 1995, PHARM PEOPL REP CH 2, P788

[7] Chemiluminescence (CL) emission generated during oxidation of pyrogallol and its application in analytical chemistry. I. Effect of oxidant compound [J].

Evmiridis, NP ;

Thanasoulias, NK ;

Vlessidis, AG .

TALANTA, 1998, 46 (01) :179-196

[8] Membrane sensors for batch and flow injection potentiometric determination of ethamsylate (Cyclonamine) in pharmaceutical preparations [J].

Hassan, SSM ;

ElBahnasawy, RM ;

Rizk, NM .

MIKROCHIMICA ACTA, 1997, 126 (3-4) :217-222

[9] CHEMILUMINESCENCE ARISING FROM SIMULTANEOUS TRANSITIONS IN PAIRS OF SINGLET OXYGEN MOLECULES [J].

KHAN, AU ;

KASHA, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (11) :3293-&

[10] Flow injection chemiluminescence determination of tetracyclines [J].

Li, Z ;

Feng, ML ;

Lu, JR ;

Gong, ZL ;

Jiang, HL .

ANALYTICAL LETTERS, 1997, 30 (04) :797-807

← 1 2 3 →