Measuring the effect of glutamate receptor agonists on extracellular D-serine concentrations in the rat striatum using online microdialysis-capillary electrophoresis

被引：24

作者：

Ciriacks, CM ^{[1
]}

Bowser, MT ^{[1
]}

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

NEUROSCIENCE LETTERS | 2006年 / 393卷 / 2-3期

关键词：

D-Serine; astrocyte; capillary electrophoresis; microdialysis; AMPA receptor; NMDA receptor;

D O I：

10.1016/j.neulet.2005.09.080

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Online microdialysis-capillary electrophoresis (CE) was used to measure the changes in extracellular D-serine concentration in response to the application of glutamate agonists and antagonists in the rat striatum. The microdialysis-CE assay was capable of measuring concentration changes as small as 8% with a sampling rate of 12-15 s. Kainic acid (KA) induced increases in D- and L-serine concentrations. Application of the non-NMDA receptor antagonist CNQX did not affect the increases observed for D- or L-serine, suggesting a nonspecific effect. NMDA also induced increases in D-serine, L-serine, glutamate and GABA concentrations. These increases were attenuated by the NMDA receptor antagonist MK-801. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：200 / 205

页数：6

共 32 条

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