Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles

被引：133

作者：

Greish, Khaled ^{[1
,2
]}

Thiagarajan, Giridhar ^{[1
,3
]}

Herd, Heather ^{[1
,3
]}

Price, Robert ^{[1
,2
]}

Bauer, Hillevi ^{[1
,2
]}

Hubbard, Dallin ^{[1
,3
]}

Burckle, Alexander ^{[1
,3
]}

Sadekar, Shraddha ^{[1
,2
]}

Yu, Tian ^{[1
,2
]}

Anwar, Arnida ^{[1
,2
]}

Ray, Abhijit ^{[1
,2
]}

Ghandehari, Hamidreza ^{[1
,2
,3
]}

机构：

[1] Univ Utah, Nano Inst Utah, Utah Ctr Nanomed, Salt Lake City, UT 84108 USA

[2] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA

[3] Univ Utah, Dept Bioengn, Salt Lake City, UT 84108 USA

来源：

NANOTOXICOLOGY | 2012年 / 6卷 / 07期

关键词：

Nanotoxicity; silica nanoparticles; PAMAM dendrimers; disseminated intravascular coagulation; biocompatibility; IN-VIVO; PAMAM DENDRIMERS; BIOMEDICAL APPLICATIONS; PLASMINOGEN-ACTIVATOR; STARBURST DENDRIMERS; CHEMISTRY; THROMBIN; BIOCOMPATIBILITY; FIBRINOGEN; PROTEINS;

D O I：

10.3109/17435390.2011.604442

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity. A distinct trend in nanotoxicity based on surface charge and functional group was observed with dendrimers regardless of their size. Amine-terminated dendrimers were fatal at doses >10 mg/kg causing haematological complications such as disseminated intravascular coagulation-like manifestations whereas carboxyl-and hydroxyl-terminated dendrimers of similar sizes were tolerated at 50-fold higher doses. In contrast, larger SNPs were less tolerated than smaller SNPs irrespective of their surface functionality. These findings have important implications in the use of these nanoparticles for various biomedical applications.

引用

页码：713 / 723

页数：11

共 30 条

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