Metabolic Regulation by p53 Family Members

被引：368

作者：

Berkers, Celia R. ^{[1
]}

Maddocks, Oliver D. K. ^{[1
]}

Cheung, Eric C. ^{[1
]}

Mor, Inbal ^{[1
]}

Vousden, Karen H. ^{[1
]}

机构：

[1] CR UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland

来源：

CELL METABOLISM | 2013年 / 18卷 / 05期

基金：

加拿大健康研究院; 欧洲研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; PROMOTES CELL-SURVIVAL; MAMMALIAN TARGET; GLUCOSE-METABOLISM; TUMOR SUPPRESSION; MESENCHYMAL DIFFERENTIATION; TRANSCRIPTIONAL PROGRAMS; P53-INDUCIBLE REGULATOR; ANTIOXIDANT RESPONSE; GENOTOXIC STRESS;

D O I：

10.1016/j.cmet.2013.06.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs.

引用

页码：617 / 633

页数：17

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