Tuning the basicity of synergic bimetallic reagents: Switching the regioselectivity of the direct dimetalation of toluene from 2,5-to 3,5-positions

被引：44

作者：

Blair, Victoria L. ^{[1
]}

Carrella, Luca M. ^{[2
]}

Clegg, William ^{[3
]}

Conway, Ben ^{[1
]}

Harrington, Ross W. ^{[3
]}

Hogg, Lorna M. ^{[1
]}

Klett, Jan ^{[1
]}

Mulvey, Robert E. ^{[1
]}

Rentschler, Eva ^{[2
]}

Russo, Luca ^{[3
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

[2] Johannes Gutenberg Univ Mainz, Inst Anorgan Chem & Analyt Chem, D-55128 Mainz, Germany

[3] Univ Newcastle Upon Tyne, Sch Nat Sci Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 33期

基金：

英国工程与自然科学研究理事会;

关键词：

alkali metals; inverse crown compounds; magnesium; manganese; metalation;

D O I：

10.1002/anie.200801158

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Meta-meta metalation: Remarkably, toluene can be directly dimanganated or dimagnesiated at the 3,5-positions using bimetallic bases with active Me3SiCH2 ligands (see scheme, blue). In contrast, n-butyl ligands lead to 2,5-metalation (red). tmp = 2,2,6,6-tetramethylpiperidide. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6208 / 6211

页数：4

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