New directions and interactions in metagenomics research

被引:32
作者
Ward, N
机构
[1] Inst Gen Res, Rockville, MD USA
[2] Ctr Marine Biotechnol, Baltimore, MD USA
关键词
metagenomic; diversity; genomic;
D O I
10.1111/j.1574-6941.2005.00055.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Metagenomics, which aims to access the genomic potential of an environmental sample directly, is a burgeoning area that is generating enormous amounts of biological information. An examination of recent metagenomics literature reveals the discipline to be heading in new and interesting directions, including the investigation of the normal flora of mammals, analysis of ancient genomes, and exploration of the distribution of novel pathways. In addition, the development of new bioinformatics approaches and tools is allowing innovative mining of both existing and new data. Finally, there are indications that the integration of metagenomics with complementary approaches in microbial ecology is beginning.
引用
收藏
页码:331 / 338
页数:8
相关论文
共 60 条
[1]   PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori [J].
Akopyants, NS ;
Fradkov, A ;
Diatchenko, L ;
Hill, JE ;
Siebert, PD ;
Lukyanov, SA ;
Sverdlov, ED ;
Berg, DE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13108-13113
[2]   PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information [J].
Angly, F ;
Rodriguez-Brito, B ;
Bangor, D ;
McNairnie, P ;
Breitbart, M ;
Salamon, P ;
Felts, B ;
Nulton, J ;
Mahaffy, J ;
Rohwer, F .
BMC BIOINFORMATICS, 2005, 6 (1)
[3]   To BAC or not to BAC:: marine ecogenomics [J].
Béjà, O .
CURRENT OPINION IN BIOTECHNOLOGY, 2004, 15 (03) :187-190
[4]   Bacterial rhodopsin:: Evidence for a new type of phototrophy in the sea [J].
Béjà, O ;
Aravind, L ;
Koonin, EV ;
Suzuki, MT ;
Hadd, A ;
Nguyen, LP ;
Jovanovich, S ;
Gates, CM ;
Feldman, RA ;
Spudich, JL ;
Spudich, EN ;
DeLong, EF .
SCIENCE, 2000, 289 (5486) :1902-1906
[5]   Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction [J].
Bergo, V ;
Amsden, JJ ;
Spudich, EN ;
Spudich, JL ;
Rothschild, KJ .
BIOCHEMISTRY, 2004, 43 (28) :9075-9083
[6]   Darwinian adaptation of proteorhodopsin to different light intensities in the marine environment [J].
Bielawski, JP ;
Dunn, KA ;
Sabehi, G ;
Béjà, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (41) :14824-14829
[7]   Here a virus, there a virus, everywhere the same virus? [J].
Breitbart, M ;
Rohwer, F .
TRENDS IN MICROBIOLOGY, 2005, 13 (06) :278-284
[8]   Metagenomic analyses of an uncultured viral community from human feces [J].
Breitbart, M ;
Hewson, I ;
Felts, B ;
Mahaffy, JM ;
Nulton, J ;
Salamon, P ;
Rohwer, F .
JOURNAL OF BACTERIOLOGY, 2003, 185 (20) :6220-6223
[9]  
Cano RJ, 2000, AM J PHYS ANTHROPOL, V112, P297
[10]   Metagenomic gene discovery: past, present and future [J].
Cowan, D ;
Meyer, Q ;
Stafford, W ;
Muyanga, S ;
Cameron, R ;
Wittwer, P .
TRENDS IN BIOTECHNOLOGY, 2005, 23 (06) :321-329