Target validation using chemical probes

被引：329

作者：

Bunnage, Mark E. ^{[1
]}

Chekler, Eugene L. Piatnitski ^{[1
]}

Jones, Lyn H. ^{[1
]}

机构：

[1] Pfizer, Worldwide Med Chem, Cambridge, MA USA

来源：

NATURE CHEMICAL BIOLOGY | 2013年 / 9卷 / 04期

关键词：

SMALL MOLECULES; INHIBITOR; IDENTIFICATION; PROTEOMICS; DISCOVERY; POTENT;

D O I：

10.1038/nchembio.1197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fully profiled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target validation. We believe that by developing a 'chemical probe tool kit', and a framework for its use, chemical biology can have a more central role in identifying targets of potential relevance to disease, avoiding many of the biases that complicate target validation as practiced currently.

引用

页码：195 / 199

页数：5

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