Timeline - Trends in large-scale mouse mutagenesis: from genetics to functional genomics

被引：61

作者：

Gondo, Yoichi

机构：

[1] Mutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg2431

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout Mouse consortium (IKMc) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. this article traces the origins and rationale of these large- scale mouse mutagenesis programmes.

引用

页码：803 / +

页数：8

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