SUBGENOMIC RNA-SYNTHESIS;
BINDER PROBE TECHNOLOGY;
TIME PCR ASSAY;
MOLECULAR CHARACTERIZATION;
PARVOVIRUS TYPE-2;
FIELD STRAINS;
GLYCOPROTEIN;
QUANTITATION;
INFECTION;
D O I:
10.1128/JVI.01937-08
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.
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页码:15332 / 1537
页数:6
相关论文
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[1]
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