Inclusion body myositis: Review of recent literature

被引:18
作者
Greenberg, Steven A. [1 ]
机构
[1] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
BETA-AMYLOID PRECURSOR; MYXOVIRUS-LIKE STRUCTURES; HUMAN MUSCLE-FIBERS; INFLAMMATORY MYOPATHIES; SKELETAL-MUSCLE; TRANSGENIC MICE; CHRONIC POLYMYOSITIS; MUSCULAR-DYSTROPHY; GENE-EXPRESSION; RIMMED VACUOLES;
D O I
10.1007/s11910-009-0013-x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.
引用
收藏
页码:83 / 89
页数:7
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