Tuning rate of the Bergman cyclization of benzannelated enediynes with ortho substituents

被引：94

作者：

Alabugin, IV ^{[1
]}

Manoharan, M ^{[1
]}

Kovalenko, SV ^{[1
]}

机构：

[1] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1021/ol0255054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.

引用

页码：1119 / 1122

页数：4

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