Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643

被引：8

作者：

Brown, MS

Dirlam, JP

McArthur, HAI

McCormick, EL

Morse, BK

Murphy, PA

O'Connell, TN

Pacey, M

Rescek, DM

Ruddock, J

Wax, RG

机构：

[1] Pfizer Inc, Cent Res, Groton, CT 06340 USA

[2] Pfizer Ltd, Cent Res, Anim Hlth Cent Res, Sandwich CT13 9NJ, Kent, England

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 08期

关键词：

D O I：

10.7164/antibiotics.52.742

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.

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收藏

页码：742 / 747

页数：6

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