Traceless chemical ligations from O-acyl serine sites

被引：16

作者：

El Khatib, Mirna ^{[1
]}

Elagawany, Mohamed ^{[1
,2
,3
]}

Jabeen, Farukh ^{[1
,4
]}

Todadze, Ekaterina ^{[1
]}

Bol'shakov, Oleg ^{[1
]}

Oliferenko, Alexander ^{[1
]}

Khelashvili, Levan ^{[1
]}

El-Feky, Said A. ^{[2
]}

Asiri, Abdullah ^{[5
]}

Katritzky, Alan R. ^{[1
,5
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Zagazig Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Zagazig 44519, Egypt

[3] Misr Univ Sci & Technol, Coll Pharm, Dept Organ Chem, Al Motamayez Dist, Egypt

[4] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[5] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 25期

关键词：

CONVENIENT SYNTHESIS; STAUDINGER LIGATION; PROTEINS; AUXILIARIES; MIGRATION; PEPTIDES;

D O I：

10.1039/c2ob07050b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.

引用

页码：4836 / 4838

页数：3

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