Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110δ mutations

被引：24

作者：

Cornillet-Lefebvre, P

Cuccuini, W

Bardet, V

Tamburini, J

Gillot, L

Ifrah, N

Nguyen, P

Dreyfus, F

Mayeux, P

Lacombe, C

Bouscary, D ^{[1
]}

机构：

[1] CHU Reims, Hematol Lab, Reims, France

[2] UPRES, EA 3796, IFR 53, Fac Med, Reims, France

[3] Univ Paris Descartes, Fac Med, Inst Cochin, INSERM,U567,CNRS,UMR 8104,Hop Cochin, F-75674 Paris, France

[4] Hop Cochin, Serv Hematol, AP HP, F-75674 Paris, France

[5] CHU Angers, Serv Malad Sang, Angers, France

[6] UPRES, EA 3863, UFR Med Angers, Angers, France

来源：

LEUKEMIA | 2006年 / 20卷 / 02期

关键词：

D O I：

10.1038/sj.leu.2404054

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：374 / 376

页数：4

共 9 条

[1] Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic [J].

Kang, SY ;

Bader, AG ;

Vogt, PK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) :802-807

[2] Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia [J].

Ozeki, K ;

Kiyoi, H ;

Hirose, Y ;

Iwai, M ;

Ninomiya, M ;

Kodera, Y ;

Miyawaki, S ;

Kuriyama, K ;

Shimazaki, C ;

Akiyama, H ;

Nishimura, M ;

Motoji, T ;

Shinagawa, K ;

Takeshita, A ;

Ueda, R ;

Ohno, R ;

Emi, N ;

Naoe, T .

BLOOD, 2004, 103 (05) :1901-1908

[3] Mutant PIK3CA promotes cell growth and invasion of human cancer cells [J].

Samuels, Y ;

Diaz, LA ;

Schmidt-Kittler, O ;

Cummins, JM ;

DeLong, L ;

Cheong, I ;

Rago, C ;

Huso, DL ;

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

CANCER CELL, 2005, 7 (06) :561-573

[4] High frequency of mutations of the PIK3CA gene in human cancers [J].

Samuels, Y ;

Wang, ZH ;

Bardelli, A ;

Silliman, N ;

Ptak, J ;

Szabo, S ;

Yan, H ;

Gazdar, A ;

Powell, DM ;

Riggins, GJ ;

Willson, JKV ;

Markowitz, S ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

SCIENCE, 2004, 304 (5670) :554-554

[5] Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia [J].

Sujobert, P ;

Bardet, V ;

Cornillet-Lefebvre, P ;

Hayflick, JS ;

Prie, N ;

Verdier, F ;

Vanhaesebroeck, B ;

Muller, O ;

Pesce, F ;

Ifrah, N ;

Hunault-Berger, M ;

Berthou, C ;

Villemagne, B ;

Jourdan, E ;

Audhuy, B ;

Solary, E ;

Witz, B ;

Harousseau, JL ;

Himberlin, C ;

Lamy, T ;

Lioure, B ;

Cahn, JY ;

Dreyfus, F ;

Mayeux, P ;

Lacombe, C ;

Bouscary, D .

BLOOD, 2005, 106 (03) :1063-1066

[6] p110 delta, a novel phosphoinositide 3-kinase in leukocytes [J].

Vanhaesebroeck, B ;

Welham, MJ ;

Kotani, K ;

Stein, R ;

Warne, PH ;

Zvelebil, MJ ;

Higashi, K ;

Volinia, S ;

Downward, J ;

Waterfield, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) :4330-4335

[7] Phosphoinositide 3-kinases: A conserved family of signal transducers [J].

Vanhaesebroeck, B ;

Leevers, SJ ;

Panayotou, G ;

Waterfield, MD .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) :267-272

[8] Survival of acute myeloid leukemia cells requires PI3 kinase activation [J].

Xu, Q ;

Simpson, SE ;

Scialla, TJ ;

Bagg, A ;

Carroll, M .

BLOOD, 2003, 102 (03) :972-980

[9] FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells [J].

Zheng, R ;

Levis, M ;

Piloto, O ;

Brown, P ;

Baldwin, BR ;

Gorin, NC ;

Beran, M ;

Zhu, ZP ;

Ludwig, D ;

Hicklin, D ;

Witte, L ;

Li, YW ;

Small, D .

BLOOD, 2004, 103 (01) :267-274

← 1 →