Iron-Mediated Radical Nitro-Cyclization Reaction of 1,6-Dienes

被引：61

作者：

Taniguchi, Tsuyoshi ^{[1
]}

Ishibashi, Hiroyuki ^{[1
]}

机构：

[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 01期

关键词：

C-H BOND; THERMAL-DECOMPOSITION; SIDE-CHAIN; NITRATION; DIOXIDE; HYDRAZINES; CONVERSION; DIENES; LIGAND; IODINE;

D O I：

10.1021/ol902510p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sequential steps that involved radical addition of a nitro group to 1,6-dienes promoted by the thermal decomposition of Iron nitrate(III) nonahydrate, cyclization, and trapping of the resulting terminal radicals by a chlorine atom in the presence of chloride salt afforded five-membered-ring compounds, The present reaction provides a practical method for the synthesis of nitro compounds due to its simple experimental procedure and Its use of nontoxic and inexpensive iron reagents.

引用

页码：124 / 126

页数：3

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