Iron-Mediated Radical Nitro-Cyclization Reaction of 1,6-Dienes

被引:61
作者
Taniguchi, Tsuyoshi [1 ]
Ishibashi, Hiroyuki [1 ]
机构
[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan
关键词
C-H BOND; THERMAL-DECOMPOSITION; SIDE-CHAIN; NITRATION; DIOXIDE; HYDRAZINES; CONVERSION; DIENES; LIGAND; IODINE;
D O I
10.1021/ol902510p
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Sequential steps that involved radical addition of a nitro group to 1,6-dienes promoted by the thermal decomposition of Iron nitrate(III) nonahydrate, cyclization, and trapping of the resulting terminal radicals by a chlorine atom in the presence of chloride salt afforded five-membered-ring compounds, The present reaction provides a practical method for the synthesis of nitro compounds due to its simple experimental procedure and Its use of nontoxic and inexpensive iron reagents.
引用
收藏
页码:124 / 126
页数:3
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