Chemoselective C-H Bond Activation: Ligand and Solvent Free Iron-Catalyzed Oxidative C-C Cross-Coupling of Tertiary Amines with Terminal, Alkynes. Reaction Scope and Mechanism

被引：173

作者：

Volla, Chandra M. Rao ^{[1
]}

Vogel, Pierre ^{[1
]}

机构：

[1] Swiss Fed Inst Technol EPFL, LGSA, CH-1015 Lausanne, Switzerland

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

MOLECULAR-OXYGEN; DIRECT ARYLATION; NITROGEN ATOM; ADJACENT; METAL; PEROXIDASE; ARYL; PROPARGYLAMINES; ALKYLATION; COMPOUND;

D O I：

10.1021/ol9002509

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

FeCl2 catalyzes the oxidative C-C cross-coupling of tertiary amines with terminal alkynes into propargylamines using (t-BuO)(2) as oxidant. The reaction can be applied to aromatic and aliphatic amines and alkynes without solvent. High chemoselectivity for aminomethyl groups is due to a steric factor.

引用

页码：1701 / 1704

页数：4

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