Directed evolution of gold nanoparticle delivery to cells

被引：89

作者：

Li, Na ^{[1
]}

Larson, Timothy ^{[2
]}

Nguyen, Hong H. ^{[1
]}

Sokolov, Konstantin V. ^{[2
]}

Ellington, Andrew D. ^{[1
]}

机构：

[1] Univ Texas Austin, Inst Cell & Mol Biol, Dept Chem & Biochem, Austin, TX 78712 USA

[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 03期

基金：

美国国家卫生研究院;

关键词：

EPIDERMAL GROWTH-FACTOR; GENE-REGULATION; RECEPTOR; APTAMER; INTERNALIZATION;

D O I：

10.1039/b920865h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A newly selected anti-receptor (anti-EGFR) aptamer was conjugated to gold nanoparticles via a facile hybridization method and was found to specifically and quantitatively direct the delivery of gold nanoparticles to cells expressing EGFR through receptor-mediated endocytosis.

引用

页码：392 / 394

页数：3

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