共 32 条
Variable host-pathogen compatibility in Mycobacterium tuberculosis
被引:758
作者:
Gagneux, S
DeRiemer, K
Van, T
Kato-Maeda, M
de Jong, BC
Narayanan, S
Nicol, M
Niemann, S
Kremer, K
Gutierrez, MC
Hilty, M
Hopewell, PC
Small, PM
机构:
[1] Inst Syst Biol, Seattle, WA 98103 USA
[2] Stanford Univ, Med Ctr, Div Infect Dis & Geog Med, Stanford, CA 94305 USA
[3] Univ Calif Davis, Sch Med, Davis, CA 95616 USA
[4] San Francisco Gen Hosp, Div Pulm & Crit Care Med, San Francisco, CA 94110 USA
[5] Univ Calif San Francisco, San Francisco, CA 94110 USA
[6] MRC Labs, Fajara, Gambia
[7] Tuberculosis Res Ctr, Dept Immunol, Madras 600031, Tamil Nadu, India
[8] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
[9] Natl Reference Ctr Mycobacteria, Forschungszentrum, D-23848 Borstel, Germany
[10] Natl Inst Publ Hlth & Environm, Mycobacteria Reference Unit, NL-3720 BA Bilthoven, Netherlands
[11] Swiss Trop Inst, CH-4002 Basel, Switzerland
[12] Inst Pasteur, Mycobacteria Reference Lab, F-75724 Paris, France
[13] Bill & Melinda Gates Fdn, Seattle, WA 98102 USA
来源:
基金:
英国惠康基金;
关键词:
coevolution;
deletions;
lineage;
polymorphism;
population;
D O I:
10.1073/pnas.0511240103
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development.
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页码:2869 / 2873
页数:5
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