Frailty and sarcopenia: definitions and outcome parameters

被引：234

作者：

Cooper, C. ^{[1
,14
]}

Dere, W. ^{[2
]}

Evans, W. ^{[3
]}

Kanis, J. A. ^{[4
]}

Rizzoli, R. ^{[5
]}

Sayer, A. A. ^{[1
]}

Sieber, C. C. ^{[6
]}

Kaufman, J-M. ^{[7
]}

van Kan, G. Abellan ^{[8
]}

Boonen, S. ^{[9
]}

Adachi, J. ^{[10
]}

Mitlak, B. ^{[11
]}

Tsouderos, Y. ^{[12
]}

Rolland, Y. ^{[8
]}

Reginster, J-Y. L. ^{[13
]}

机构：

[1] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[2] Amgen Ltd, Uxbridge, Middx, England

[3] GlaxoSmithKline, Muscle Metab Discovery Unit, Res Triangle Pk, NC USA

[4] Univ Sheffield, WHO Collaborating Ctr Metab Bone Dis, Sheffield, S Yorkshire, England

[5] Univ Hosp Geneva, Geneva, Switzerland

[6] Univ Erlangen Nurnberg, Inst Biomed Aging, D-91054 Erlangen, Germany

[7] Ghent Univ Hosp, Dept Endocrinol & Lab Hormonol, Ghent, Belgium

[8] Toulouse Univ Hosp, Dept Geriatr Med, INSERM Unit 1027, Toulouse, France

[9] Leuven Univ, Div Gerontol & Geriatr, Louvain, Belgium

[10] McMaster Univ, Hamilton, ON, Canada

[11] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

[12] Servier, Paris, France

[13] Univ Liege, Liege, Belgium

[14] Univ Oxford, Inst Musculoskeletal Sci, Oxford, England

来源：

OSTEOPOROSIS INTERNATIONAL | 2012年 / 23卷 / 07期

关键词：

Assessment; Frailty; Outcome; Pathophysiology; Sarcopenia; Treatment; LIFE-STYLE INTERVENTIONS; HORMONE-BINDING GLOBULIN; BODY-COMPOSITION; SKELETAL-MUSCLE; ELDERLY-MEN; MOBILITY LIMITATION; PHYSICAL FUNCTION; ANDROGEN LEVELS; GROWTH-HORMONE; GAIT SPEED;

D O I：

10.1007/s00198-012-1913-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.

引用

页码：1839 / 1848

页数：10

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