Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: A long-term follow-up study

被引：27

作者：

Haginoya, Kazuhiro ^{[1
,2
]}

Miyabayashi, Shigeaki ^{[3
]}

Kikuchi, Masahiro ^{[4
]}

Kojima, Akira ^{[5
]}

Yamamoto, Katsuya ^{[6
]}

Omura, Kiyoshi ^{[7
]}

Uematsu, Mitsugu ^{[2
]}

Hino-Fukuyo, Naomi ^{[2
]}

Tanaka, Soichiro ^{[1
]}

Tsuchiya, Shigeru ^{[2
]}

机构：

[1] Takuto Rehabil Ctr Children, Dept Pediat Neurol, Taihaku Ku, Sendai, Miyagi 9820241, Japan

[2] Tohoku Univ, Sch Med, Dept Pediat, Sendai, Miyagi 9808574, Japan

[3] Miyabayashi Kodomo Clin, Sendai, Miyagi, Japan

[4] Hitachi Gen Hosp, Dept Pediat, Hitachi, Ibaraki, Japan

[5] Kojima Pediat Clin, Adachi Ku, Tokyo, Japan

[6] Nankodai Yamamoto Childrens Clin, Sendai, Miyagi, Japan

[7] Natl Nishitaga Hosp, Dept Pediat, Sendai, Miyagi, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2009年 / 278卷 / 1-2期

关键词：

Leigh syndrome; Idebenone; Mitochondrial encephalopathy; Respiratory failure; C OXIDASE DEFICIENCY; MITOCHONDRIAL ENCEPHALOMYOPATHY; METABOLISM; BRAIN; COENZYME-Q10; MELAS; RATS; ABNORMALITIES; MONOAMINES; SEROTONIN;

D O I：

10.1016/j.jns.2008.11.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Respiratory failure can be the direct cause of death in patients with Leigh syndrome. Unfortunately, no effective treatment strategy is available. Here, we report successful treatment of a patient with Leigh syndrome using idebenone, a derivative of coenzyme Q-10. The patient's brainstem function, especially respiratory function, improved after idebenone treatment. Idebenone may be worth trying in patients with Leigh syndrome. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：112 / 114

页数：3

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